Georgetown Lombardi Visiting Professor and Grand Rounds Lecture Series: “Dissecting the Therapy Resistance Landscape of Acral Lentiginous Melanoma”
Title: “Dissecting the Therapy Resistance Landscape of Acral Lentiginous Melanoma”
Vito Rebecca, PhD
Assistant Professor, Biochemistry and Molecular Biology Department, Johns Hopkins Bloomberg School of Public Health
Joint Appointment in Oncology, Johns Hopkins School of Medicine
Lecture Series Presented by Georgetown Lombardi Comprehensive Cancer Center
About the Speaker:
The Rebecca laboratory focuses on understanding genetic and non-genetic mechanisms of therapy resistance and metastasis leveraged by cancer cells, using acral lentiginous melanoma as a paradigm. Their particular focus is on stem cell-like tumor cell subpopulations of melanoma cells that “hijack” developmental signaling cassettes to drive transient metastatic and drug resistant cell states. Their studies encompass quantitative tools, genetic editing, molecular biology, in vivo patient-derived xenograft therapy trials and bioinformatic analyses to arrive at a comprehensive understanding of actionable vulnerabilities for stem cell-like subpopulations of cancer cells.