Distinguished Scientist Seminar Series featuring Ezra Burstein, MD, PhD – “Endosomal protein sorting and its regulation by the CCC and Retriever complexes”
Distinguished Scientist Seminar Series
Ezra Burstein, MD, PhD
Professor, Internal Medicine & Molecular Biology
Division Chief, Digestive and Liver Diseases
UT Southwestern Medical Center
Title & Abstract:
“Endosomal protein sorting and its regulation by the CCC and Retriever complexes”
The plasma membrane (PM) proteome includes receptors, transporters, channels, and myriad other factors, which altogether represent nearly 11% of all proteins in human cells. With the constant flux of membranes to and from the cell surface, PM proteins are frequently internalized into the endosomal system, where they need to be sent back to the cell surface for recycling or routed to lysosomes for degradation. Given the indispensable cellular functions of many PM proteins, the process of endosomal recycling is essential to cellular homeostasis. This presentation will review two recently reported regulators of this process, the CCC and Retriever multimeric protein complexes, and present unpublished data on their structural organization and function.