Dean’s Seminar Series featuring E. Dale Abel, MD, PhD – “(Glucose Metabolism) a Common Soil Linking Diabetes Mellitus, Heart Failure and Cancer?”
***CME/CE Credit is being offered for this Seminar***
E. Dale Abel, MD, PhD
François M. Abboud Chair in Internal Medicine
John B. Stokes III Chair in Diabetes Research
Chair and Departmental Executive Officer, Department of Internal Medicine
Director, Fraternal Order of Eagles Diabetes Research Center
Professor of Medicine, Biochemistry and Biomedical Engineering
University of Iowa, Carver College of Medicine
(Glucose Metabolism) a Common Soil Linking Diabetes Mellitus, Heart Failure and Cancer?
Heart failure is a disease of aging that continues to have a poor prognosis. Diabetes Mellitus amplifies the risk of heart failure. Heart failure and diabetes are accompanied by impaired mitochondrial oxidative capacity in the heart. Moreover, heart failure and diabetes are insulin resistant states. An important consequence of these systemic and organ-specific metabolic changes is a mismatch between glucose uptake and its mitochondrial metabolism that leads to the accumulation of glycolytic intermediates that activate signaling pathways that contribute to ventricular remodeling. Many of these perturbations in glycolytic metabolism are also seen in cancer. Whereas activation of these pathways lead to cellular proliferation in cancer, in the heart they promote myocardial remodeling. Metabolic modulation may play an important role in ameliorating the progression of heart failure.