Center for Metabolomic Studies Seminar Series Featuring Clary B. Clish, PhD
Presentation: “Approaches for Nontargeted Metabolomics at Scale and Application to Study Cardiometabolic Disease, Diet, and the Microbiome”
Speaker: Clary B. Clish, PhD
Senior Director, Metabolite Profiling
Institute Scientist, Broad Institute of MIT and Harvard
Our lab uses liquid chromatography tandem mass spectrometry (LC-MS)-based metabolomics to study disease in human cohorts and model systems. Our metabolomics workflows, including analytical methods and informatics tools and approaches, will be described. The presentation will also highlight recent work to identify metabolites associated with incident cardiometabolic disease in human cohorts, current efforts to study metabolic profiles characteristic of diet, and identification of metabolites linked to the microbiome.
About the Speaker:
Clary Clish is senior director of the Metabolomics Platform at the Broad Institute of MIT and Harvard, where he is also an institute scientist. Prior to joining the Broad Institute, Clish held senior and executive management positions in the biotechnology industry from 2001-2008, including Vice President of Discovery at Gene Logic Inc. and Director of Metabolite Biochemistry at Beyond Genomics Inc. From 1997-2001, Clish was a postdoctoral fellow and instructor in the laboratory of Dr. Charles Serhan at the Center for Experimental Therapeutics and Reperfusion Injury at Brigham & Women’s Hospital. In the Serhan laboratory, his work focused on understanding the roles of lipid mediators in acute inflammation and its resolution, including his discovery and initial characterization of the class of anti-inflammatory lipid mediators named “resolvins.” He received his BSc from McGill University in chemistry and biological sciences and his PhD from Portland State University.