Lecture

Department of Microbiology & Immunology Seminar: “Applying Animal Models of the Cancer-Causing Gammaherpesviruses to Identify Immune Correlates of Protection and Determinants of Oncogenesis”

Name: Department of Microbiology & Immunology Seminar: “Applying Animal Models of the Cancer-Causing Gammaherpesviruses to Identify Immune Correlates of Protection and Determinants of Oncogenesis”
Start: 2023-10-03T12:15:00-04:00
End: 2023-10-03T13:15:00-04:00
Location: MED NE301 and via Zoom

Title: “Applying Animal Models of the Cancer-Causing Gammaherpesviruses to Identify Immune Correlates of Protection and Determinants of Oncogenesis”

Speaker:
Laurie Krug, PhD
Stadtman Investigator, HIV and AIDS Malignancy Branch, Center for Cancer Research, National Cancer Institute

Abstract:
My laboratory uses animal models to identify and investigate virus-host interactions that are critical for chronic gammaherpesvirus infection and oncogenesis. With regard to my murine gammaherpesvirus research program, I will report on the role of host STAT3 in B cell latency and the use of novel replication- and latency-defective viral vaccines that have identified immune correlates of protection from wild-type virus challenge. My laboratory’s translational research program aims to apply pre-clinical animal models to develop effective interventions against cancers caused by Kaposi sarcoma herpesvirus. I will report on the establishment and characterization of Kaposi sarcoma patient-derived xenografts in immune-deficient mice.