Dean’s Seminar Series featuring Mary Klotman, MD – “Academic Medicine: Mission Critical”
***CME/CE Credit is being offered for this Seminar***
Mary E. Klotman, MD
Dean, Duke University School of Medicine
Vice Chancellor for Health Affairs, Duke University
Academic Medicine: Mission Critical
Part I: Through the last 35 years, Academic Health Systems have faced a number of acute and chronic crises, particularly in public health. The core missions, when well executed, are mission critical to finding solutions as has certainly been the case in HIV and is a sustaining focus through the challenge of COVID. Leadership through these crises requires a competent team, a clear organizational structure, data-driven decision making, as well as clear, credible and continuous communication. A common theme in finding solutions in HIV and COVID is effective partnerships between industry, NIH and academic institutions.
Part 2: HIV-associated nephropathy (HIVAN) was the most common kidney disease in people living with HIV before anti-retroviral therapy (ART) was available. Animal models and human biopsy studies established the causal relationship between HIVAN and direct HIV infection of renal epithelial cells expression of viral genes in the kidney. While widespread use of ART has dramatically decreased HIVAN infection, HIV enhances the comorbid kidney diseases common with aging of the HIV population. Furthermore, the kidney remains a site for viral persistence and therefore a potential reservoir for HIV with implications for both HIV cure initiatives as well as the transplantation of kidneys between HIV positive individuals. This presentation will demonstrate the in vivo evidence supporting the kidney as a unique viral compartment and long term reservoir and the fate of virus during kidney transplantation between HIV-1 positive donor and recipient pairs.