Dean’s Seminar Series featuring Mariana Kaplan, MD – “Neutrophils in the pathogenesis of chronic inflammatory diseases”
Dean’s Seminar Series
Mariana Kaplan, MD
Chief, Systemic Autoimmunity Branch
Deputy Scientific Director, National Institute of Arthritis and Musculoskeletal and Skin Diseases
Title & Abstract:
“Neutrophils in the pathogenesis of chronic inflammatory diseases”
Recent discoveries have led to a significant resurgence of interest in neutrophils as shapers of immune dysregulation and as triggers of organ damage in chronic inflammatory diseases. Neutrophils contribute to the initiation, promotion, and perpetuation of immune dysregulation through a variety of mechanisms. This presentation will highlight recent advances in our understanding of how neutrophil dysregulation modulates the innate and adaptive immune responses in chronic inflammatory diseases and their putative contributions to pathogenicity. Understanding the potential pathogenic role of neutrophil dysregulation may provide better molecular candidates for therapeutic targeting, and ultimately promote improvements in the clinical outcomes in these diseases.