Center for Metabolomic Studies Seminar Series: “Using Lipidomics to Understand How Human T cells Control Outcomes of Infection and Autoimmune Disease”
Branch Moody, MD
Professor of Medicine, Harvard Medical School
Associate Physician, Brigham and Women’s Hospital
Presentation: “Using Lipidomics to Understand How Human T cells Control Outcomes of Infection and Autoimmune Disease”
By using lipids and tetramers to study the function of CD1-restricted T cells in healthy humans and in disease states, recent studies have identified new populations of human T cells, including IL-22 secreting CD1a autoreactive T cells and germline encoded mycolyl reactive (GEM) T cells. Our overall goal is to develop a basic understanding of the cellular mechanisms that allow T cells to discriminate among self and foreign antigens, so that these antigens and adjuvants can be developed as immunomodulatory agents and vaccines for treatment of patients.