Center for Metabolomic Studies Seminar Series Featuring Marcia C. Haigis, PhD
Presentation: “The Role of Metabolites in Cancer and Anti-tumor Immunity”
Speaker: Marcia C. Haigis, PhD
Professor in the Department of Cell Biology
Director of Gender Equity for Faculty in Science
Harvard Medical School
Mitochondria are dynamic organelles that provide cells with energy and metabolites needed for survival and growth even during dramatic changes in diet, stress and development. Metabolic rewiring is a hallmark of cancer and supports the increased biosynthetic and energetic requirements of cancer cells. The tumor microenvironment provides a unique niche that supports the metabolic reprogramming of the tumor but may be suppressive to cytotoxic T cells. Additionally, metabolites serve as key signaling molecules and enable communication within cells and between cells. Here I will discuss our work in elucidating how metabolites impact anti-tumor immune control.